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Charles Eyer
Professor Emeritus

After completing a Bachelor of Pharmacy degree at Washington State University in Pullman, Washington, Charles Eyer returned from a brief hiatus for military service and completed his Ph. D. in Pharmaceutical Sciences at the same institution in 1976.  Dr. Eyer accepted an appointment at The University of Montana and progressed through the academic ranks to Professor of Pharmacology/Toxicology.   In 1993, he took advantage of a sabbatical leave at Purdue University to change his research focus to neurotoxicology.

RESEARCH STATEMENT
Research in the Eyer laboratory focuses on the mechanism of action of organotin compounds.  This is part of a larger area of investigation on the effects of environmental exposure to both neurotoxic and non-neurotoxic compounds on glial-neuronal interactions and the outcomes of neurologic diseases.  In vitro approaches are being employed to invesitigate the role of glia in neuronal damage produced by environmental toxins and how this interaction affects the outcome of stroke and other diseases that destroy neurons.
KEY PUBLICATIONS
Eyer C.L., Rio C., and Smith J.R. Trimethyltin Reduces ATP levels and MTT Reduction in the LRM55 Rat Astrocytoma Cell Line. In Vitro & Molec. Toxicol. 13(4): 263-268 (2001).

Karpiak V.C., Bridges R.J., and Eyer C.L. Organotins Disrupt Components Of Glutamate Homeostasis In Rat Astrocyte Cultures. J. Toxicol. Environ. Health 63: 110-115 (2001).

Liu L., Bridges R.J., and Eyer C.L. Effect of Cytochrome P450 1A Induction On Oxidative Damage In Rat Brain. In press, Molec. Cell. Biochem. May 2001.

Karpiak V.C., and Eyer C.L. Differential Gliotoxicity Of Organotins. Cell Biol. Toxicol. 15: 261-268 (1999).